ABSTRACT
BACKGROUND: Hypertension has been reported as the most prevalent comorbidity in patients with coronavirus disease 2019 (COVID-19). This retrospective study aims to compare the clinical characteristics and outcomes in COVID-19 patients with or without hypertension. METHODS: A total of 944 hospitalized patients with laboratory-confirmed COVID-19 were included from January to March 2020. Information from the medical record, including clinical features, radiographic and laboratory results, complications, treatments, and clinical outcomes, were extracted for the analysis. RESULTS: A total of 311 (32.94%) patients had comorbidity with hypertension. In COVID-19 patients with hypertension, the coexistence of type 2 diabetes (56.06% vs 43.94%), coronary heart disease (65.71% vs 34.29%), poststroke syndrome (68.75% vs 31.25%) and chronic kidney diseases (77.78% vs 22.22%) was significantly higher, while the coexistence of hepatitis B infection (13.04% vs 86.96%) was significantly lower than in COVID-19 patients without hypertension. Computed tomography (CT) chest scans show that COVID-19 patients with hypertension have higher rates of pleural effusion than those without hypertension (56.60% vs 43.40%). In addition, the levels of blood glucose [5.80 (IQR, 5.05-7.50) vs 5.39 (IQR, 4.81-6.60)], erythrocyte sedimentation rate (ESR) [28 (IQR, 17.1-55.6) vs 21.8 (IQR, 11.5-44.1), P=0.008], C-reactive protein (CRP) [17.92 (IQR, 3.11-46.6) vs 3.15 (IQR, 3.11-23.4), P=0.013] and serum amyloid A (SAA) [99.28 (IQR, 8.85-300) vs 15.97 (IQR, 5.97-236.1), P=0.005] in COVID-19 patients with hypertension were significantly higher than in patients without hypertension. CONCLUSION: It is common for patients with COVID-19 to have the coexistence of hypertension, type 2 diabetes, coronary heart disease and so on, which may exacerbate the severity of COVID-19. Therefore, optimal management of hypertension and other comorbidities is essential for better clinical outcomes.
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ABSTRACT: As Corona Virus Disease 2019 (COVID-19) has been gradually controlled domestically, various industries began to resume production in an orderly way. Attention should be paid to the disease and population characteristics of patients with cleft lip with/without palate during diagnosis and treatment. This article summarized and provided prevention and control recommendations on management strategies during hospitalization and protective measures of patients and healthcare workers, hoping to minimize the spread of disease and create a relatively safe environment for medical work.
Subject(s)
COVID-19 , Cleft Lip , Cleft Palate , China/epidemiology , Cleft Lip/epidemiology , Cleft Palate/epidemiology , Cleft Palate/surgery , Humans , Pandemics , SARS-CoV-2ABSTRACT
Objective: To develop .scientific and practical management strategies for pregnancy with novel coronavirus infection, so as to provide reference for clinical treatment of pregnancy with SARS-CoV-2 infection. Methods: Management strategies for pregnancy with SARS-CoV-2 infection were initially compiled, which was based on the literature researching and clinical treatment experience analysis. Then management strategies were modified by using Delphi method. Results: Management strategies for pregnancy with SARS-CoV-2 infection were compiled. There were totally 24 entries, involving 8 dimensions. Both of positive coefficients in two rounds of expert consultations were 100%. And both authoritative coefficients were 0. 91. And coordination coefficients ranged from 0. 24 to 0. 39. After two rounds of expert consultations, the importance values of each dimension varied from 4. 73 to 4. 89. Coefficients of variation(CV) of each dimension ranged from 0. 06 to 0. 14. And importance values of each item were different from 4. 71 to 4. 90. And CV of each item varied from 0. 05 to 0. 18. Conclusion: On the basis of Delphi method, compiled management strategies for pregnancy with SARS-CoV-2 infection are scientific and practical. And it can provide a reference for clinical fight against pregnancy with novel coronavirus infection.